Product Description

RARβ Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3328-50, ES3328-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: RARB, HAP, NR1B2, Retinoic acid receptor beta, RAR-beta, HBV-activated protein, Nuclear receptor subfamily 1 group B member 2, RAR-epsilon

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human Retinoic Acid Receptor beta. AA range:331-380

Isotype: IgG

Target: RARβ

Specificity: RARβ Polyclonal Antibody detects endogenous levels of RARβ protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in aortic endothelial cells (at protein level),

Observed Band (KD): 50kD

Fields: Pathways in cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer

Function: Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain
Function: This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression
Similarity: Belongs to the nuclear hormone receptor family
Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
Similarity: Contains 1 nuclear receptor DNA-binding domain

Subcellular Location: Nucleus Cytoplasm, [Isoform Beta-1]: Nucleus, [Isoform Beta-2]: Nucleus, [Isoform Beta-4]: Cytoplasm

Storage and Stability: -20°C/1 year

Gene Name: RARB

Protein Name: Retinoic acid receptor beta

Mouse Gene ID: 218772

Mouse SwissProt Number: P22605

Research Use Only