Product Description

RASA1 Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS46138-50, BS46138-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimμlates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resμlting in the inactive GDP-bound form of RAS, thereby allowing control of cellμlar proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing resμlts in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adμlt tissues. [provided by RefSeq, May 2012]

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, ICC/IF

Alternate Names: GAP, PKWS, RASA, p120, CMAVM, CM-AVM, CMAVM1, RASGAP, p120GAP, p120RASGAP

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human RASA1

Dilution: WB: 1:1000 IHC: 1:20 ICC/IF: 1:50

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 140 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P20936

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only