Product Description

RASSF8 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3830-50, ES3830-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12, 22)(p11.2, q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011],

Reactivity: Human, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: RASSF8, C12orf2, Ras association domain-containing protein 8, Carcinoma-associated protein HOJ-1

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from RASSF8. at AA range: 60-140

Isotype: IgG

Target: RASSF8

Specificity: RASSF8 Polyclonal Antibody detects endogenous levels of RASSF8 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Widely expressed as a 6,2 kb transcript, A 2,2 kb alternatively spliced transcript is expressed exclusively in testis,

Observed Band (KD): 48kD

Function: Disease: A chromosomal aberration involving RASSF8 is found in a complex type of synpolydactyly, also referred to as 3/3-prime/4 synpolydactyly associated with metacarpal and metatarsal synostoses [MIM: 608180]. Reciprocal translocation t(12, 22)(p11.2, q13.3) with FBLN1
Similarity: Contains 1 Ras-associating domain
Tissue Specificity: Widely expressed as a 6.2 kb transcript. A 2.2 kb alternatively spliced transcript is expressed exclusively in testis

Storage and Stability: -20°C/1 year

Gene Name: RASSF8

Protein Name: Ras association domain-containing protein 8

Mouse SwissProt Number: Q8CJ96

Research Use Only