Product Description

RBQ-3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES7008-50, ES7008-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: RBBP5, RBQ3, Retinoblastoma-binding protein 5, RBBP-5, Retinoblastoma-binding protein RBQ-3

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from RBQ-3. at AA range: 190-270

Isotype: IgG

Target: RBQ-3

Specificity: RBQ-3 Polyclonal Antibody detects endogenous levels of RBQ-3 protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitously expressed,

Observed Band (KD): 59kD

Fields: Cushing syndrome

Function: Function: Binds preferentially to underphosphorylated retinoblastoma protein
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR
Similarity: Contains 6 WD repeats
Subunit: Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1
Tissue Specificity: Ubiquitously expressed

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: RBBP5

Protein Name: Retinoblastoma-binding protein 5

Mouse Gene ID: 213464

Mouse SwissProt Number: Q8BX09

Research Use Only