Product Description

RD3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES13432-50, ES13432-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a retinal protein that is associated with promyelocytic leukemia-gene product (PML) bodies in the nucleus. Mutations in this gene cause Leber congenital amaurosis type 12, a disease that results in retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA, IHC

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human RD3 AA range: 126-176

Isotype: IgG

Target: RD3

Specificity: This antibody detects endogenous levels of RD3 at Human/Mouse

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in retina (PubMed:12914764), Widely expressed (at protein level) (PubMed:29030614), In the retina the strongest immunoreactivity is detected in the inner half of the cytoplasmic portion of the photoreceptor layer, where rods and cones are found, and the external half of the outer plexiform layer (at protein level) (PubMed:29030614),

Molecular Weight (Da): 21kD

Function: Disease: Defects in RD3 are the cause of Leber congenital amaurosis type 12 (LCA12) [MIM: 610612]. LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children
Tissue Specificity: Preferentially expressed in retina

Subcellular Location: Cell projection, cilium, photoreceptor outer segment Photoreceptor inner segment Endosome Nucleus Cytoplasm Cytoplasm, perinuclear region Colocalizes with GUCY2E and GUCY2F in rods and cones photoreceptors Colocalizes with GUK1 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer (By similarity) Strong dot-like perinuclear staining in the epithelial cells (PubMed:29030614)

Storage and Stability: -20°C/1 year

Gene Name: RD3 C1orf36

Protein Name: RD3

Mouse Gene ID: 74023

Mouse SwissProt Number: Q8BRE0

Research Use Only