Recombinant ApoER2 Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: E-AB-81530-50, E-AB-81530-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: ApoER2
Target Synonym: MCI1; LRP-8; APOER2; HSZ75190
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Rat, Hamster
Application: WB
Isotype: IgG
Clonality: Rabbit Monoclonal
Clone No.: R03-1H8
UNIProt ID: Q14114
Background: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 . Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells .
Concentration: 300 μg/mL
Immunogen: A synthetic peptide of human ApoER2
Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Purification Method: Affinity Purified
Dilution: WB 1:500-1:2000
Calculated MW: 106kDa
Observed MW: 106kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only