Recombinant Axin 2 Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: E-AB-81534-50, E-AB-81534-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: Axin 2
Target Synonym: AXIN2; AXIL; ODCRCS; axin-2
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Neuroscience, Stem Cells
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Application: WB
Isotype: IgG
Clonality: Rabbit Monoclonal
Clone No.: R06-3A8
UNIProt ID: Q9Y2T1
Background: The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Concentration: 300 μg/mL
Immunogen: A synthetic peptide of human Axin 2
Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Purification Method: Affinity Purified
Dilution: WB 1:500-1:1000
Calculated MW: 94kDa
Observed MW: 94kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only