Recombinant Glucocorticoid Receptor Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: E-AB-81561-50, E-AB-81561-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: Glucocorticoid Receptor
Target Synonym: GR; GCR; GRL; GCCR; GCRST
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Application: WB, IF
Isotype: IgG
Clonality: Rabbit Monoclonal
Clone No.: R04-8C8
UNIProt ID: P06537
Background: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:10678832). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546).
Concentration: 300 μg/mL
Immunogen: Recombinant protein of mouse Glucocorticoid Receptor
Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Purification Method: Affinity Purified
Dilution: WB 1:500-1:1000 IF 1:50-1:100
Calculated MW: 86kDa
Observed MW: 94/91kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only