Recombinant Human CD46 Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP00279-10, RP00279-20, RP00279-50, RP00279-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human CD46 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys35-Asp328) of human CD46 (Accession #NP_758861.1) fused with a 6×His tag at the C-terminus.
Alternate Names: AHUS2, MCP, MIC10, TLX, TRA2.10, CD46
SWISS: P15529-11
GeneID: 4179
Species: Human
Purity: ≥ 90 % as determined by SDS-PAGE.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: The recombinant human CD46 consists of 305 amino acids with a molecular weight of 34 kDa. The apparent molecular mass of recombinant human CD46 is about 55-60 kDa in SDS-PAGE under reducing conditions due to glycosylation.CD46 is also known as MCP and is a type I membrane protein that functions as a cofactor for Complement Factor I-mediated inactivation of complement components C3b and C4b. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2),a disease characterized by uncontrolled complement activation.
Source: HEK293 cells
Tag: C-His
Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Antigen Sequence: CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLD
Endotoxin: < 0.1 EU/μg of the protein by LAL method.
Research Use Only