Recombinant Human GITRL protein(His tag)
Sizes: 20μg, 100μg
Catalogue Numbers: PDMH100033-20, PDMH100033-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: GITRL
Target Synonym: Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL
UNIProt ID: Q9UNG2
Target Species: Human
Expression Host: HEK293 Cells
Fusion Tag: C-His
Accession: Q9UNG2
Background: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1.Promotes leukocyte adhesion to endothelial cells .Regulates migration of monocytes from the splenic reservoir to sites of inflammation.
Sequence: Leu49-Ser177
Purity: > 90 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: Please contact us for more information.
Calculated MW: 14.6 kDa
Observed MW: 15 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only