Product Description

Recombinant Human IL-1b

Size: 10µg

Catalogue Number: EPT039-10

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: IL1B belongs to the IL-1 family. Interleukin 1 (IL-1) is a family of polypeptide cytokines consisting of two agonists, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2) encoded by two distinct genes and perform identical biological functions. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response. It is identified as endogenous pyrogens, and is reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Description: Recombinant Human Interleukin-1 Beta is produced by our E. coli expression system and the target gene encoding Ala117-Ser269 is expressed.

Alternate Names: Interleukin-1 beta, Catabolin, IL1F2, IL1B

Purity: Greater than 95% as determined by reducing SDS-PAGE.

Biological Activity: Measured by its ability to induce NF-kB signaling in 293-IL1 Res cells (Cat#XCC10) . The ED50 for this effect is 20-100 pg/ml.

Endotoxin: Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.

Molecular Weight: 17.5 KDa

Observed Molecular Weight: 17 KDa, reducing conditions

Storage: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Storage Conditions: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Delivery Condition: The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

Accession: P01584

Research Use Only