Recombinant Human IL-23 Recetor/IL-23R Protein (His Tag) - PKSH032578

Recombinant Human IL-23 Recetor/IL-23R Protein (His Tag)

Sizes: 10μg, 50μg

Catalogue Numbers: PKSH032578-10, PKSH032578-50

Citations, Manuals and MSDS Available upon request.

Abbreviation: IL-23 Recetor; IL-23R

Target Synonym: Interleukin-23 receptor; IL23R; IL-23 receptor; IL-23R

UNIProt ID: Q5VWK5

Research Areas: Signal Transduction; epigenetics and nuclear signal; immunology;

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-6His

Accession: Q5VWK5

Background: Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits; the IL12Rβ1 subunit; which is shared with several cytokines; and a subunit that is unique to IL-23. IL23; after binding to IL23R; activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells; NK cells; dendritic cells; and macrophages. In fact; polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis; multiple sclerosis; Graves's ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.

Sequence: Gly24-Asp353

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 38.7 kDa

Observed MW: 60-90 kDa

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Research Use Only