Recombinant Human PKAβcat/PRKACB protein (His tag)
Size: 100μg
Catalogue Numbers: PDEH100360-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: PKAβcat; PRKACB
Target Synonym: cAMP-dependent protein kinase catalytic subunit beta; PRKACB; PKA C-beta
UNIProt ID: P22694
Research Areas: Cancer;
Metabolism; signal Transduction
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-His & C-His
Accession: P22694
Background: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
Sequence: Gly 2-Phe 351
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: Please contact us for more information.
Calculated MW: 38.39 kDa
Observed MW: 42 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only