Recombinant Mouse HP1α protein (His tag)
Size: 100μg
Catalogue Numbers: PDEM100072-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: HP1α
Target Synonym: HP1 alpha; Antigen p25; CBX5; Chromobox 5; Epididymis luminal protein 25; HEL25; Heterochromatin protein 1; HP1A
UNIProt ID: Q61686
Research Areas: Epigenetics and Nuclear Signaling; Tags & Cell Markers
Target Species: Mouse
Expression Host: E.coli
Fusion Tag: N-His
Accession: Q61686
Background: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Sequence: Met 1-Ser 191
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: Please contact us for more information.
Calculated MW: 20.9 kDa
Observed MW: 25 kDa
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Research Use Only