Product Description

RelB Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES7028-50, ES7028-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: caution:Was originally (PubMed:1577270) thought to inhibit the transcriptional activity of nuclear factor NF-kappa-B.,domain:Both N- and C-terminal domains are required for transcriptional activation.,function:NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49.,induction:By mitogens.,PTM:Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation.,similarity:Contains 1 RHD (Rel-like) domain.,subunit:Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex. Self-associates, the interaction seems to be transient and may prevent degradation allowing for heterodimer formation with p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID.,

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA, IHC

Alternate Names: RELB, Transcription factor RelB, I-Rel

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human RelB. AA range:530-579

Isotype: IgG

Target: RelB

Specificity: RelB Polyclonal Antibody detects endogenous levels of RelB protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Blood, T-cell,

Observed Band (KD): 62kD

Fields: MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection

Function: Caution: Was originally (PubMed: 1577270) thought to inhibit the transcriptional activity of nuclear factor NF-kappa-B
Domain: Both N- and C-terminal domains are required for transcriptional activation
Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-k

Subcellular Location: Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Colocalizes with NEK6 in the centrosome

Storage and Stability: -20°C/1 year

Gene Name: RELB

Protein Name: Transcription factor RelB

Mouse Gene ID: 19698

Mouse SwissProt Number: Q04863

Research Use Only