Product Description

RGS16 (phospho Tyr168) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES7044-50, ES7044-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Applications: WB, ELISA, IHC

Alternate Names: RGS16, RGSR, Regulator of G-protein signaling 16, RGS16, A28-RGS14P, Retinal-specific RGS, RGS-r, hRGS-r, Retinally abundant regulator of G-protein signaling

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human RGS16 around the phosphorylation site of Tyr168. AA range:141-190

Isotype: IgG

Target: RGS16

Specificity: Phospho-RGS16 (Y168) Polyclonal Antibody detects endogenous levels of RGS16 protein only when phosphorylated at Y168.

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Abundantly expressed in retina with lower levels of expression in most other tissues,

Observed Band (KD): 30kD

Function: Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in regulating the kinetics of signaling in the phototransduction cascade
PTM: Palmitoylated on Cys-2 and/or Cys-12
PTM: Phosphorylation on Tyr-168 upon EGFR stimulation. Enhanced GTPase accelerating (GAP) activity on G(i)-alpha
Similarity: Contains 1 RGS domain
Tissue Specificity: Abundantly expressed in retina with lower levels of expression in most other tissues

Subcellular Location: Membrane, Lipid-anchor

Storage and Stability: -20°C/1 year

Gene Name: RGS16

Protein Name: Regulator of G-protein signaling 16

Mouse Gene ID: 19734

Mouse SwissProt Number: P97428

Rat SwissProt Number: P56700

Research Use Only