Product Description

Ribosomal Protein L11 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES7068-50, ES7068-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA, IHC

Alternate Names: RPL11, 60S ribosomal protein L11, CLL-associated antigen KW-12

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from Ribosomal Protein L11. at AA range: 100-180

Isotype: IgG

Target: Ribosomal Protein L11

Specificity: Ribosomal Protein L11 Polyclonal Antibody detects endogenous levels of Ribosomal Protein L11 protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Amygdala, Cervix carcinoma, Tonsil,

Observed Band (KD): 20kD

Fields: Ribosome, Coronavirus disease - COVID-19

Function: Disease: Defects in RPL11 are the cause of Diamond-Blackfan anemia type 7 (DBA7) [MIM: 612562]. DBA7 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies
Function: Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits
Similarity: Belongs to the ribosomal protein L5P family

Subcellular Location: Nucleus, nucleolus Cytoplasm

Storage and Stability: -20°C/1 year

Gene Name: RPL11

Protein Name: 60S ribosomal protein L11

Mouse Gene ID: 67025

Mouse SwissProt Number: Q9CXW4

Rat SwissProt Number: P62914

Research Use Only