Product Description

RIP Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES13391-50, ES13391-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA, IHC

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human RIP AA range: 117-167

Isotype: IgG

Target: RIP

Specificity: This antibody detects endogenous levels of RIP at Human/Mouse/Rat

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Widely expressed, Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen,

Molecular Weight (Da): 24kD

Function: Function: Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism
PTM: Isoform 2 is sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues
Similarity: Contains 1 RIP-type zinc finger
Subcellular Location: Only nuclear, localizes to PML body
Subunit: Interacts with the RPA1 subunit of RPA complex
Tissue Specificity: Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis

Subcellular Location: [Isoform 1]: Cytoplasm Nucleus, [Isoform 2]: Nucleus, PML body

Storage and Stability: -20°C/1 year

Gene Name: RPAIN RIP

Protein Name: RIP

Mouse Gene ID: 69723

Mouse SwissProt Number: Q9CWY9

Rat Gene ID: 287463

Rat SwissProt Number: Q4G2Y1

Research Use Only