Product Description

RP1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES13346-50, ES13346-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Transcript variants resulted from an alternative promoter and alternative splicings have been found, which overlap the current reference sequence and has several exons upstream and downstream of the current reference sequence. However, the biological validity and full-length nature of some variants cannot be determined at this time.[provided by RefSeq, Sep 2010],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA, IHC

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human RP1 AA range: 1330-1380

Isotype: IgG

Target: RP1

Specificity: This antibody detects endogenous levels of RP1 at Human/Mouse

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in retina, Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, spleen and pancreas,

Molecular Weight (Da): 237kD

Function: Disease: Defects in RP1 are the cause of retinitis pigmentosa type 1 (RP1) [MIM: 180100]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well
Function: Could have a role in the differentiation of photoreceptor cells
Online Information: Retina International's Scientific Newsletter,Online Information: Retinal information network,Similarity: Contains 2 doublecortin domains
Tissue Specificity: Expressed in retina. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, spleen and pancreas

Subcellular Location: Cytoplasm, cytoskeleton, cilium axoneme Cell projection, cilium, photoreceptor outer segment Specifically localized in the connecting cilia of rod and cone photoreceptors

Storage and Stability: -20°C/1 year

Gene Name: RP1 ORP1

Protein Name: RP1

Mouse Gene ID: 19888

Mouse SwissProt Number: P56716

Research Use Only