Product Description

RPH3L Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES13335-50, ES13335-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human RPH3L AA range: 162-212

Isotype: IgG

Target: RPH3L

Specificity: This antibody detects endogenous levels of RPH3L at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver, Also detected in epithelial cells,

Molecular Weight (Da): 35kD

Function: Domain: The N-terminus of the RabBD domain is necessary and sufficient for interaction with RAB27A
Function: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells
Similarity: Contains 1 FYVE-type zinc finger
Similarity: Contains 1 RabBD (Rab-binding) domain
Subcellular Location: Recruited to the vesicle membrane in a GTP-and RAB3B-dependent manner in epithelial cells
Subunit: Recruited to dense-core vesicles through specific interaction with RAB27A in endocrine cells. Interacts with RAB3A, RAB3B, RAB3C and RAB3D. Interacts with ZYX
Tissue Specificity: Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells

Subcellular Location: Cytoplasm Cytoplasmic vesicle, secretory vesicle membrane Recruited to the vesicle membrane in a GTP- and RAB3B-dependent manner in epithelial cells

Storage and Stability: -20°C/1 year

Gene Name: RPH3AL NOC2

Protein Name: RPH3L

Mouse Gene ID: 380714

Mouse SwissProt Number: Q768S4

Rat Gene ID: 171123

Rat SwissProt Number: O54880

Research Use Only