RUNX1T1 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A1737-20, A1737-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t (8;21) (q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Rat
Protein Weight: 68kDa
Observed Molecular Weight: 68kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 862
SWISS: Q06455
Alternate Names: CDR; ETO; MTG8; AML1T1; ZMYND2; CBFA2T1; AML1-MTG8; RUNX1T1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Cancer, Tumor suppressors.
NCBI Alias: RUNX1T1
Research Use Only