Product Description

SAC2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES13217-50, ES13217-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human SAC2 AA range: 1006-1056

Isotype: IgG

Target: SAC2

Specificity: This antibody detects endogenous levels of SAC2 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous (PubMed:11274189), Highly expressed in brain (PubMed:26203138),

Molecular Weight (Da): 125kD

Fields: Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

Function: Function: Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-triphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation
Miscellaneous: Inositol polyphosphate 5-phosphatases usually have 2 conserved motifs that are essential for 5-phosphatase activity. However, INPP5F does not contain such motifs, and phosphatase activity seems to exist in the SAC domain, suggesting a new type of phosphoinositide 5-phosphatase
Similarity: Contains 1 SAC domain
Tissue Specificity: Ubiquitous

Subcellular Location: Membrane, clathrin-coated pit Early endosome Recycling endosome Also found on macropinosomes

Storage and Stability: -20°C/1 year

Gene Name: INPP5F KIAA0966 SAC2 MSTP007 MSTP047

Protein Name: SAC2

Mouse Gene ID: 101490

Mouse SwissProt Number: Q8CDA1

Research Use Only