Product Description

SAFB2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES13214-50, ES13214-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Scaffold attachment factor B2 (SAF-B2)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human SAFB2 AA range: 737-787

Isotype: IgG

Target: SAFB2

Specificity: This antibody detects endogenous levels of SAFB2 at Human/Mouse

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.226% sodium azide.

Expression: Expressed at high levels in the CNS and at low levels in the liver, Expressed in a wide number of breast cancer cell lines,

Observed Band (KD): 105kD

Function: Function: Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR
Similarity: Contains 1 RRM (RNA recognition motif) domain
Similarity: Contains 1 SAP domain
Subunit: Interacts with SAFB/SAFB1 and SCAM1
Tissue Specificity: Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines

Subcellular Location: Cytoplasm Nucleus

Storage and Stability: -20°C/1 year

Gene Name: SAFB2 KIAA0138

Protein Name: SAFB2

Mouse Gene ID: 224902

Mouse SwissProt Number: Q80YR5

Research Use Only