Product Description

SAMHD1 (phospho-Thr592) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES13204-50, ES13204-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1(SAMHD1) Homo sapiens This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: SAM domain and HD domain-containing protein 1 (EC 3.1.4.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5)

Clonality: Polyclonal

Immunogen: Synthesized phosho peptide around human SAMHD1 (Thr592)

Isotype: IgG

Target: SAMHD1

Specificity: This antibody detects endogenous levels of Human Mouse Rat SAMHD1 (phospho-Thr592)

Dilution: WB 1:1000-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes (PubMed:11064105), No expression is seen in brain and thymus (PubMed:11064105),

Observed Band (KD): 72kD

Fields: Viral life cycle - HIV-1, Human immunodeficiency virus 1 infection

Function: Function: May play a role in mediating proinflammatory responses to TNF-alpha signaling
Induction: By interferon gamma. Up-regulated in TNF-alpha treated lung fibroblasts
Similarity: Contains 1 HD domain
Similarity: Contains 1 SAM (sterile alpha motif) domain
Tissue Specificity: Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus

Subcellular Location: Nucleus Chromosome Localizes to sites of DNA double-strand breaks in response to DNA damage

Storage and Stability: -20°C/1 year

Gene Name: SAMHD1 MOP5

Protein Name: SAMHD1 (Thr592)

Mouse Gene ID: 56045

Mouse SwissProt Number: Q60710

Research Use Only