SARM1 Polyclonal Antibody - BT-AP14045

SARM1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP14045-20, BT-AP14045-50, BT-AP14045-100

Citations, Manuals and MSDS Available upon request.

Background: Was initially reported to contain ARM repeats (PubMed:11386760). Such repeats are however not predicted by any detection method.,Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.,Contains 1 TIR domain.,Contains 2 SAM (sterile alpha motif) domains.,subunit:Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function.,tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta.,

Research Areas: Cell biology; Immunology; Signal transduction

Target Protein: SARM1

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Sterile alpha and TIR motif-containing protein 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q6SZW1; Mouse: Q6PDS3

Synonyms: Sterile alpha and TIR motif-containing protein 1;Sterile alpha and Armadillo repeat protein;Sterile alpha motif domain-containing protein 2;SAM domain-containing protein 2;Tir-1 homolog

GeneID: Human: 23098

Research Use Only