SCNNA Polyclonal Antibody - BT-AP14082

SCNNA Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP14082-20, BT-AP14082-50, BT-AP14082-100

Citations, Manuals and MSDS Available upon request.

Background: Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Research Areas: Neuroscience; Signal transduction; Metabolism

Target Protein: SCNN1A

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Amiloride-sensitive sodium channel subunit alpha

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P37088; Mouse: Q61180; Rat: P37089

Synonyms: Amiloride-sensitive sodium channel subunit alpha;Alpha-NaCH;Epithelial Na;+ channel subunit alpha;Alpha-ENaC;ENaCA;Nonvoltage-gated sodium channel 1 subunit alpha;SCNEA

GeneID: Human: 6337

Research Use Only