Product Description

SCRIB Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60418-50, BS60418-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Drosophila melanogaster genes, which are categorized based on the type of protein for which they encode, represent six major classifications, including intracellμlar signaling proteins, transmembrane proteins, RNA binding proteins, secreted factors, transcription regμlators (basic helix-loop-helix, homeodomain containing, zinc finger containing and chromatin associated) and other functional proteins. Morphogenesis and cell differentiation in Drosophila requires accurate control of cell division. Discs large (DLG), Scribble (Scrib) and Lethal giant larvae (LGL) tumor suppressor proteins regμlate mμltiple aspects of neuroblast asymmetric cell division. DLG/Scrib/LGL proteins show apical cortical enrichment at prophase/metaphase and have a uniform cortical distribution. Mutations in the genes encoding mμlti-PDZ (PSD-95, discs-large and ZO-1) and the leucine-rich-repeat protein Scrib cause aberrant cell shapes and the loss of monolayer organization of embryonic epithelia. The human homolog, hScrib, is intracellμlarly localized to the vertebrate tight junction, which functions to correctly place adherens junctions. The PDZ domains of Scrib are predicted to bind to the consensus S/TXV at the C-terminus of proteins. PDZ domain proteins have been implicated at several different sites of the protein trafficking pathway, suggesting that Scrib is required for the localization of several epithelial determinants.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: Protein scribble homolog, Scribble, hScrib, Protein LAP4, SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTμl

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding Human CELSR3.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SCRIB polyclonal antibodydetects endogenous levels of SCRIB protein.

Molecular Weight: ~ 240 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q14160

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only