Product Description

SCYL1BP1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4099-50, ES4099-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: golgin, RAB6 interacting(GORAB) Homo sapiens This gene encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. The encoded protein may function in the secretory pathway. The encoded protein, which also localizes to the cytoplasm, was identified by interactions with the N-terminal kinase-like protein, and thus it may function in mitosis. Mutations in this gene have been associated with geroderma osteodysplastica. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA, IHC

Alternate Names: GORAB, NTKLBP1, SCYL1BP1, RAB6-interacting golgin, N-terminal kinase-like-binding protein 1, NTKL-BP1, NTKL-binding protein 1, hNTKL-BP1, SCY1-like 1-binding protein 1, SCYL1-BP1, SCYL1-binding protein 1

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human GORAB. AA range:1-50

Isotype: IgG

Target: SCYL1BP1

Specificity: SCYL1BP1 Polyclonal Antibody detects endogenous levels of SCYL1BP1 protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Embryo, Pancreas, Testis, Trachea,

Observed Band (KD): 45kD

Fields: p53 signaling pathway

Function: Caution: It is uncertain whether Met-1 or Met-26 is the initiator
Disease: Defects in GORAB are the cause of geroderma osteodysplasticum (GO) [MIM: 231070], also known as gerodermia osteodysplastica or Walt Disney dwarfism. GO is a rare autosomal recessive disorder characterized by lax, wrinkled skin, joint laxity and a typical face with a prematurely aged appearance. Skeletal signs include severe osteoporosis leading to frequent fractures, malar and mandibular hypoplasia and a variable degree of growth retardation
Similarity: Belongs to the GORAB family
Subunit: Interacts with SCYL1 (By similarity). Interacts with RCHY1 and RAB6A/RAB6

Subcellular Location: Cytoplasm Golgi apparatus

Storage and Stability: -20°C/1 year

Gene Name: GORAB

Protein Name: RAB6-interacting golgin

Mouse Gene ID: 98376

Mouse SwissProt Number: Q8BRM2

Rat Gene ID: 304923

Rat SwissProt Number: B1H222

Research Use Only