Product Description

SDS3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES13172-50, ES13172-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: SDS3 is a subunit of the histone deacetylase (see HDAC1, MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human SDS3 AA range: 96-146

Isotype: IgG

Target: SDS3

Specificity: This antibody detects endogenous levels of SDS3 at Human/Mouse

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in various cancer cell ines,

Molecular Weight (Da): 36kD

Function: Domain: The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms
Function: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways (By similarity). May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes
Similarity: Belongs to the SDS3 family
Subunit: Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex (By similarity). Interacts with HCFC1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2
Tissue Specificity: Expressed in various cancer cell ines.

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: SUDS3 SAP45 SDS3

Protein Name: SDS3

Mouse Gene ID: 71954

Mouse SwissProt Number: Q8BR65

Research Use Only