Product Description

SEC61B Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES13170-50, ES13170-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC, ELISA

Alternate Names: Protein transport protein Sec61 subunit beta

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human SEC61B AA range: 30-110

Isotype: IgG

Target: SEC61B

Specificity: This antibody detects endogenous levels of human SEC61B

Dilution: IHC-p 1:50-200, ELISA(peptide)1:5000-20000

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Embryonic kidney, Epithelium, Stomach mucosa,

Fields: Protein export, Protein processing in endoplasmic reticulum, Phagosome, Vibrio cholerae infection

Function: Function: Necessary for protein translocation in the endoplasmic reticulum
Similarity: Belongs to the SEC61-beta family
Subunit: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed of SEC61, SEC62 and SEC63. Interacts with SEC62

Subcellular Location: Endoplasmic reticulum membrane, Single-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: SEC61B

Protein Name: SEC61B

Research Use Only