SEMA4D Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-52208-60, E-AB-52208-120, E-AB-52208-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: SEMA4D
Target Synonym: A8; BB 18; BB18; CD 100; CD100; CD100 antigen; Coll 4; COLL4; Collapsin 4; Collapsin4; GR3; Leukocyte activation antigen CD100; M sema G; MSEMA; SEM4D; Sema 4d; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain semaphorin 4D; Sema H; SEMA J; Sema4d; Semacl 2; Semacl2; SemaH; SEMAJ; Semaphorin 4D; Semaphorin C like 2; Semaphorin H; Semaphorin J; Semaphorin-4D; Semaphorin4D; SemaphorinJ; Semcl 2; Semcl2
Research Areas: Cancer, Immunology, Neuroscience
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse
Application: IHC, ELISA
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q92854
Background: Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.
Concentration: 0.4 mg/mL
Immunogen: Fusion protein of human SEMA4D
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification Method: Antigen affinity purification
Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only