SH2B3 Polyclonal Antibody - BT-AP14183

SH2B3 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP14183-20, BT-AP14183-50, BT-AP14183-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Areas: Immunology; Signal transduction

Target Protein: SH2B3

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: SH2B adapter protein 3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9UQQ2; Mouse: O09039; Rat: P50745

Synonyms: SH2B adapter protein 3;Lymphocyte adapter protein;Lymphocyte-specific adapter protein Lnk;Signal transduction protein Lnk

GeneID: Human: 10019

Research Use Only