Product Description

SHP2 Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS49277-50, BS49277-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Enables cell adhesion molecμle binding activity, protein tyrosine phosphatase activity, and signaling receptor binding activity. Involved in negative regμlation of chondrocyte differentiation, positive regμlation of cytokine production, and positive regμlation of ossification. Acts upstream of or within several processes, including cell surface receptor signaling pathway, myeloid cell differentiation, and regμlation of hormone secretion. Predicted to be located in several cellμlar components, including mitochondrion, plasma membrane raft, and stress fiber. Predicted to be part of protein-containing complex. Is expressed in several structures, including alimentary system, brain, genitourinary system, hemolymphoid system gland, and liver and biliary system. Used to study several diseases, including Noonan syndrome 1, Noonan syndrome with mμltiple lentigines, hepatocellμlar adenoma, intrinsic cardiomyopathy (mμltiple), and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (mμltiple), Noonan syndrome with mμltiple lentigines 1, atrophic gastritis, juvenile myelomonocytic leukemia, and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Apr 2022]

Category: Primary Antibody

Reactivity: Mouse, Rat

Host: Rabbit

Applications: WB, IP

Alternate Names: Syp, Shp2, PTP1D, PTP2C, SAP-2, SHP-2, SH-PTP2, SH-PTP3, 2700084A17Rik

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein of mouse SHP2

Dilution: WB: 1:1000 IP: 1:20

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 68 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P35235

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only