SIGIR Polyclonal Antibody - BT-AP14223

SIGIR Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP14223-20, BT-AP14223-50, BT-AP14223-100

Citations, Manuals and MSDS Available upon request.

Background: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.,Belongs to the interleukin-1 receptor family.,Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,Contains 1 TIR domain.,subunit:Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6.,tissue specificity:Mainly expressed in epithelial tissues such as kidney, lung and gut.,

Research Areas: Immunology

Target Protein: SIGIRR

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Single Ig IL-1-related receptor

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q6IA17; Mouse: Q9JLZ8; Rat: Q4V892

Synonyms: Single Ig IL-1-related receptor;Single Ig IL-1R-related molecule;Single immunoglobulin domain-containing IL1R-related protein;Toll/interleukin-1 receptor 8;TIR8

GeneID: Human: 59307

Research Use Only