Product Description

SIGIR Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA34858-50, RA34858-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: function:Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP., similarity:Belongs to the interleukin-1 receptor family., similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain., similarity:Contains 1 TIR domain., subunit:Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6., tissue specificity:Mainly expressed in epithelial tissues such as kidney, lung and gut.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 45

Protein Molecular Weight (kDa): 45

Storage: -20°C/1 year

Human Gene ID: 59307

Human SwissProt Number: Q6IA17

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only