SIR4 Polyclonal Antibody - BT-AP14232

SIR4 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP14232-20, BT-AP14232-50, BT-AP14232-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

Research Areas: Cardiovascular; Cell biology; Epigenetics and nuclear signaling; Metabolism; Signal transduction

Target Protein: SIRT4

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: NAD-dependent protein deacetylase sirtuin-4

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9Y6E7; Mouse: Q8R216

Synonyms: NAD-dependent protein deacetylase sirtuin-4;EC 3.5.1.-;NAD-dependent ADP-ribosyltransferase sirtuin-4;EC 2.4.2.-;Regulatory protein SIR2 homolog 4;SIR2-like protein 4

GeneID: Human: 23409

Research Use Only