Product Description

SNF8 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES13038-50, ES13038-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins to the lysosome for degradation. This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human SNF8 AA range: 78-128

Isotype: IgG

Target: SNF8

Specificity: This antibody detects endogenous levels of SNF8 at Human/Mouse/Rat

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 28kD

Fields: Endocytosis

Function: Function: Component of the ESCRT-II complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL
Similarity: Belongs to the SNF8 family
Subunit: Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45 (By similarity). Component of the endosomal sorting required for transport complex II (ESCRT-II), composed of SNF8, VPS25 and VPS36. Interacts with TSG101, VPS25 and VPS36

Subcellular Location: Cytoplasm Endosome membrane Nucleus Late endosome membrane Recruited to the endosome membrane to participate in vesicle formation

Storage and Stability: -20°C/1 year

Gene Name: SNF8 EAP30

Protein Name: SNF8

Mouse Gene ID: 27681

Mouse SwissProt Number: Q9CZ28

Rat Gene ID: 287645

Rat SwissProt Number: Q5RK19

Research Use Only