SOCS-3 Polyclonal Antibody - BT-AP14358

SOCS-3 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP14358-20, BT-AP14358-50, BT-AP14358-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

Research Areas: Signal transduction; Immunology; Epigenetics and nuclear signaling; Metabolism; Cancer

Target Protein: SOCS3

Applications: WB, IHC-p, IF

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Suppressor of cytokine signaling 3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O14543; Mouse: O35718; Rat: O88583

Synonyms: Suppressor of cytokine signaling 3;SOCS-3;Cytokine-inducible SH2 protein 3;CIS-3;STAT-induced STAT inhibitor 3;SSI-3; Suppressor of cytokine signaling 3; SOCS-3; Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3; SSI-3

GeneID: Human: 9021; Mouse: 12702

Research Use Only