Product Description

SOCS7 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA34941-50, RA34941-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: domain:The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation., function:Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins., induction:By IL6, prolactin and growth hormone., pathway:Protein modification; protein ubiquitination., sequence caution:Contaminating sequence. The N-terminus may be contaminated with vector sequence., sequence caution:Translated as stop., similarity:Contains 1 SH2 domain., similarity:Contains 1 SOCS box domain., subunit:Interacts with phosphorylated IRS4 and PIK3R1 (By similarity). Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, IRS1, PLCG1, SORBS3/vinexin, and phosphorylated STAT3 and STAT5., tissue specificity:Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.,

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 63

Protein Molecular Weight (kDa): 63

Storage: -20°C/1 year

Human Gene ID: 30837

Human SwissProt Number: O14512

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only