Product Description

SODE Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES13022-50, ES13022-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA, IHC

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human SODE AA range: 67-117

Isotype: IgG

Target: SODE

Specificity: This antibody detects endogenous levels of SODE at Human/Mouse/Rat

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in blood vessels, heart, lung, kidney and placenta, Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid,

Molecular Weight (Da): 26kD

Function: Catalytic Activity: 2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Cofactor: Binds 1 copper ion per subunit
Cofactor: Binds 1 zinc ion per subunit
Function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Function: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen
Online Information: Superoxide dismutase entry,polymorphism: The variant Gly-231 which is found in about 2.2% of individual displays a 10-fold increased plasma EC-SOD content due to reduced heparin-binding affinity and thus the impairment of its binding ability to endothelial cell surface
Similarity: Belongs to the Cu-Zn superoxide dismutase family
Subcellular Location: 99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the v

Subcellular Location: Secreted, extracellular space Golgi apparatus, trans-Golgi network 99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium

Storage and Stability: -20°C/1 year

Gene Name: SOD3

Protein Name: SODE

Mouse Gene ID: 20657

Mouse SwissProt Number: O09164

Rat Gene ID: 25352

Rat SwissProt Number: Q08420

Research Use Only