Product Description

Sos 2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES7253-50, ES7253-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a regulatory protein that is involved in the positive regulation of ras proteins. Mutations in this gene are associated with Noonan Syndrome-9. [provided by RefSeq, Jul 2016],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA, IHC

Alternate Names: SOS2, Son of sevenless homolog 2, SOS-2

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human SOS2. AA range:631-680

Isotype: IgG

Target: Sos 2

Specificity: Sos 2 Polyclonal Antibody detects endogenous levels of Sos 2 protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Placenta,

Observed Band (KD): 150kD

Fields: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Chemokine signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Thermogenesis, Neurotrophin signaling pathway, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Relaxin signaling pathway, Growth hormone synthesis, secretion and action, Alcoholism, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Che

Function: Function: Promotes the exchange of Ras-bound GDP by GTP
Online Information: Son of sevenless entry,Similarity: Contains 1 DH (DBL-homology) domain
Similarity: Contains 1 N-terminal Ras-GEF domain
Similarity: Contains 1 PH domain
Similarity: Contains 1 Ras-GEF domain

Subcellular Location: intracellular, cytosol,

Storage and Stability: -20°C/1 year

Gene Name: SOS2

Protein Name: Son of sevenless homolog 2

Mouse SwissProt Number: Q02384

Research Use Only