Product Description

SPG16 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES12992-50, ES12992-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]).[supplied by OMIM, Jul 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA, IHC

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human SPG16 AA range: 520-570

Isotype: IgG

Target: SPG16

Specificity: This antibody detects endogenous levels of SPG16 at Human/Mouse

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Isoform 1 is detected in testis, Isoform 4 is detected in testis and brain, and at lower levels in kidney, heart, pancreas, thyroid, ovary, adrenal gland, spinal cord, trachea and liver,

Molecular Weight (Da): 69kD

Function: Function: Necessary for sperm flagellar function
Similarity: Contains 7 WD repeats
Subcellular Location: Detected on the sperm flagellum. Detected in the central apparatus of the axoneme. Colocalizes with SPAG6 on microtubules
Subunit: Interacts with SPAG6
Tissue Specificity: Isoform 1 is detected in testis. Isoform 4 is detected in testis and brain, and at lower levels in kidney, heart, pancreas, thyroid, ovary, adrenal gland, spinal cord, trachea and liver

Subcellular Location: Cytoplasm Cytoplasm, cytoskeleton, flagellum axoneme Cytoplasm, cytoskeleton, cilium axoneme Cell projection, cilium, flagellum Detected on the sperm flagellum axoneme Detected in the central apparatus of the axoneme Colocalizes with SPAG6 on microtubules (By similarity)

Storage and Stability: -20°C/1 year

Gene Name: SPAG16 PF20

Protein Name: SPG16

Mouse Gene ID: 66722

Mouse SwissProt Number: Q8K450

Research Use Only