Product Description

SPP2A Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES12985-50, ES12985-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human SPP2A AA range: 66-116

Isotype: IgG

Target: SPP2A

Specificity: This antibody detects endogenous levels of SPP2A at Human/Mouse

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous,

Molecular Weight (Da): 57kD

Function: Function: Functions as an intramembrane protease. Functions in ITM2B processing
Similarity: Belongs to the peptidase A22B family
Similarity: Contains 1 PA (protease associated) domain
Subunit: Interacts with ITM2B

Subcellular Location: Late endosome membrane, Multi-pass membrane protein Lysosome membrane, Multi-pass membrane protein Membrane, Multi-pass membrane protein, Lumenal side Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane

Storage and Stability: -20°C/1 year

Gene Name: SPPL2A IMP3 PSL2 PSEC0147

Protein Name: SPP2A

Mouse Gene ID: 66552

Mouse SwissProt Number: Q9JJF9

Research Use Only