Product Description

SPTC2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES12972-50, ES12972-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human SPTC2 AA range: 273-323

Isotype: IgG

Target: SPTC2

Specificity: This antibody detects endogenous levels of SPTC2 at Human/Mouse

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.100% sodium azide.

Expression: Widely expressed,

Observed Band (KD): 60kD

Fields: Sphingolipid metabolism, Metabolic pathways, Sphingolipid signaling pathway

Function: Catalytic Activity: Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2)
Cofactor: Pyridoxal phosphate
Pathway: Lipid metabolism, sphingolipid metabolism
Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family
Subunit: SPTLC1, SPTLC2 and SPTLC3 may encode subunits of the enzyme
Tissue Specificity: Widely expressed

Subcellular Location: Endoplasmic reticulum membrane, Single-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: SPTLC2 KIAA0526 LCB2

Protein Name: SPTC2

Mouse Gene ID: 20773

Mouse SwissProt Number: P97363

Research Use Only