Product Description

SSX2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES12941-50, ES12941-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X, 18)(p11.2, q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human SSX2 AA range: 16-66

Isotype: IgG

Target: SSX2

Specificity: This antibody detects endogenous levels of SSX2 at Human

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed at high level in the testis, Expressed at low level in thyroid, Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles, Detected in rhabdomyosarcoma and fibrosarcoma cell lines, Not detected in mesenchymal and epithelial cell lines,

Molecular Weight (Da): 21kD

Fields: Transcriptional misregulation in cancer

Function: Disease: A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation t(X, 18)(p11.2, q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency)
Function: Could act as a modulator of transcription
Similarity: Belongs to the SSX family
Similarity: Contains 1 KRAB-related domain
Subunit: Interacts via its N-terminal region with RAB3IP and SSX2IP
Tissue Specificity: Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: SSX2 SSX2A, SSX2B

Protein Name: SSX2

Research Use Only