Product Description

Stathmin (phospho-Ser16) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES12915-50, ES12915-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA, IHC

Alternate Names: Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10)

Clonality: Polyclonal

Immunogen: Synthesized phosho peptide around human Stathmin (Ser16)

Isotype: IgG

Target: Stathmin

Specificity: This antibody detects endogenous levels of Human Mouse Rat Stathmin (phospho-Ser16)

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Neuron specific,

Observed Band (KD): 20kD

Function: Function: May play a role in neuronal differentiation, and in modulating membrane interaction with the cytoskeleton during neurite outgrowth
PTM: Sumoylated
Similarity: Belongs to the stathmin family
Subcellular Location: Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms
Tissue Specificity: Neuron specific

Subcellular Location: Cytoplasm Cytoplasm, perinuclear region Cell projection, growth cone Membrane, Peripheral membrane protein, Cytoplasmic side Cell projection, axon Golgi apparatus Endosome Cell projection, lamellipodium Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons SCG10 exists in both soluble and membrane-bound forms Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity) Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons Colocalized with CIB1 to the leading edge of lamellipodia

Storage and Stability: -20°C/1 year

Gene Name: STMN2 SCG10 SCGN10

Protein Name: Stathmin (Ser16)

Mouse Gene ID: 20257

Mouse SwissProt Number: P55821

Rat Gene ID: 84510

Rat SwissProt Number: P21818

Research Use Only