Product Description

STX8 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES12886-50, ES12886-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA, IHC

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human STX8 AA range: 42-92

Isotype: IgG

Target: STX8

Specificity: This antibody detects endogenous levels of STX8 at Human/Mouse/Rat

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Highly expressed in heart, Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas,

Molecular Weight (Da): 26kD

Fields: SNARE interactions in vesicular transport

Function: Function: Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER
Similarity: Belongs to the syntaxin family
Similarity: Contains 1 t-SNARE coiled-coil homology domain
Subcellular Location: Preferentially associated with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and coated pits
Subunit: Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8
Tissue Specificity: Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas

Subcellular Location: Membrane, Single-pass type IV membrane protein Preferentially associated with the early endosome To a lesser extent, also present in late endosome, the plasma membrane and coated pits (By similarity)

Storage and Stability: -20°C/1 year

Gene Name: STX8

Protein Name: STX8

Mouse Gene ID: 55943

Mouse SwissProt Number: O88983

Rat Gene ID: 59074

Rat SwissProt Number: Q9Z2Q7

Research Use Only