Product Description

SYNJ2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES12859-50, ES12859-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human SYNJ2 AA range: 145-195

Isotype: IgG

Target: SYNJ2

Specificity: This antibody detects endogenous levels of SYNJ2 at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 165kD

Fields: Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

Function: Alternative Products: Additional isoforms seem to exist,Catalytic Activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
Domain: The C-terminal proline-rich region of isoform 2B2 mediates binding to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2
Function: Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis
Similarity: Belongs to the synaptojanin family
Similarity: Contains 1 RRM (RNA recognition motif) domain
Similarity: Contains 1 SAC domain
Similarity: In the central section, belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family
Subcellular Location: Predominantly associated with the particulate fractions
Subunit: Binds to GRB2. Isoform 2A binds to SYNJ2BP/

Subcellular Location: Cytoplasm Cell membrane Membrane raft Cell junction, synapse, presynapse Cytoplasm, cytoskeleton Localizes at presynapse terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity) Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340)

Storage and Stability: -20°C/1 year

Gene Name: SYNJ2 KIAA0348

Protein Name: SYNJ2

Mouse Gene ID: 20975

Mouse SwissProt Number: Q9D2G5

Rat Gene ID: 84018

Rat SwissProt Number: O55207

Research Use Only