Product Description

Synuclein-α (D119) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3429-50, BS3429-100

Sizes: 50µl, 100µl

Swiss-Prot: P37840

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: The synuclein family members, including α-synuclein (also designated NACP for non-β Amyloid component) and β-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. α-synuclein is localized to neuronal cell bodies and synapses. α-synuclein was first identified as a component of Alzheimer’s disease amyloid plaques. Abnormal platelet function in Alzheimer’s disease has been demonstrated. During megakaryocytic differentiation α-synuclein has been found to be upregulated, while β-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of α-synuclein has been found in patients with early onset Parkinson’s disease.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Synuclein-α (D119) polyclonal antibody detects endogenous levels of Synuclein-α protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Synuclein-α (D119) pAb at 1:500 dilution
Lane 1: SK-OVCAR3 whole cell lysate (40ug)
Lane 2: HEK293T whole cell lysate (10ug)
Lane 3: The Brain tissue lysate of Mouse (40ug)
Lane 4: The Brain tissue lysate of Rat (40ug), Immunohistochemistry (IHC) analyzes of Synuclein-α (D119) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 18 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Alpha-synuclein; α-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; SNCA; NACP; PARK1

Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human Synuclein-α.

Conjugate: Unconjugated

Modification: Unmodified