Product Description

TACC1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES7329-50, ES7329-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: TACC1, KIAA1103, Transforming acidic coiled-coil-containing protein 1, Gastric cancer antigen Ga55, Taxin-1

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human TACC1. AA range:11-60

Isotype: IgG

Target: TACC1

Specificity: TACC1 Polyclonal Antibody detects endogenous levels of TACC1 protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Isoform 1, isoform 3 and isoform 5 are ubiquitous, Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer, Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues, Down-regulated in a subset of cases of breast cancer,

Observed Band (KD): 87kD

Function: Alternative Products: Additional isoforms seem to exist,Developmental Stage: Expressed at high level during early embryogenesis
Function: Likely involved in the processes that promote cell division prior to the formation of differentiated tissues
Miscellaneous: Down-regulated in a subset of cases of breast cancer
PTM: Isoform 1 is heavily phosphorylated, isoform 6 is not. Phosphorylated upon DNA damage, probably by ATM or ATR
Similarity: Belongs to the TACC family
Similarity: Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains
Subcellular Location: Nucleus during interphase. Weakly concentrated at centrosomes during mitosis
Subunit: Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with the Aurora kinases A and B (STK6 and AURKB). Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF
Tissue Specificity: Isoform 1, isoform 3 and isoform 5 a

Subcellular Location: Cytoplasm Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Midbody Nucleus during interphase Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis, [Isoform 5]: Membrane, Lipid-anchor, [Isoform 10]: Cytoplasm

Storage and Stability: -20°C/1 year

Gene Name: TACC1

Protein Name: Transforming acidic coiled-coil-containing protein 1

Mouse Gene ID: 320165

Mouse SwissProt Number: Q6Y685

Research Use Only